Interazioni tra farmaci
Aceclofenac + Sulphasalazine
Gravità: Moderata
Aceclofenac and Sulphasalazine: moderate interaction.
Ultimo aggiornamento
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Sintesi
Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.
Cosa significa questa interazione in parole semplici
Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Sulphasalazine belongs to Gastrointestinal Tract.
Perché avviene
Additive NSAID effects on platelet function, gastric mucosa and renal prostaglandins.
Cosa fare
Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Sulphasalazine
- Deferiprone + Sulphasalazine Maggiore
- Pexidartinib + Sulphasalazine Maggiore
- Sepiapterin + Sulphasalazine Maggiore
- Acalabrutinib + Sulphasalazine Moderata
- Acetazolamide + Sulphasalazine Moderata
- Asciminib + Sulphasalazine Moderata
Altre interazioni di Aceclofenac
- Aceclofenac + Ketorolac Controindicata
- Aceclofenac + Amiloride Maggiore
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Maggiore
- Aceclofenac + Azilsartan-chlorthalidone Maggiore
- Aceclofenac + Captopril-hydrochlorothiazide Maggiore
- Aceclofenac + Celecoxib Maggiore
Domande frequenti
Can I take Aceclofenac with Sulphasalazine?
MediHelp rates the interaction as moderate. Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.
How serious is the interaction between Aceclofenac and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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