Interazioni tra farmaci
Adenovirus types 4 and 7 live + Cladribine
Gravità: Controindicata
Adenovirus types 4 and 7 live and Cladribine: contraindicated interaction.
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Sintesi
Cladribine causes prolonged lymphopenia and immunosuppression. The live oral adenovirus vaccine could replicate unchecked and cause vaccine-related infection, and the vaccine response may be poor.
Cosa significa questa interazione in parole semplici
Adenovirus types 4 and 7 live and Cladribine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Cladribine-induced lymphocyte depletion impairs immunity, allowing live attenuated virus replication and reducing vaccine efficacy.
Cosa fare
Do not give live vaccines during cladribine treatment or while lymphocyte counts remain low after it. Vaccinate at least 4 to 6 weeks before starting cladribine, and check lymphocyte recovery before any later live vaccine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Cladribine
- Cladribine + Siponimod Controindicata
- Cladribine + Tofacitinib Controindicata
- Axicabtagene ciloleucel + Cladribine Maggiore
- Belatacept + Cladribine Maggiore
- Brexucabtagene autoleucel + Cladribine Maggiore
- Cholera vaccine + Cladribine Maggiore
Domande frequenti
Can I take Adenovirus types 4 and 7 live with Cladribine?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Cladribine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphopenia and immunosuppression. The live oral adenovirus vaccine could replicate unchecked and cause vaccine-related infection, and the vaccine response may be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Cladribine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during cladribine treatment or while lymphocyte counts remain low after it. Vaccinate at least 4 to 6 weeks before starting cladribine, and check lymphocyte recovery before any later live vaccine.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Siponimod, Tofacitinib, Axicabtagene ciloleucel. The full list is on the Cladribine page.
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