Interazioni tra farmaci
Adenovirus types 4 and 7 live + Fludarabine
Gravità: Controindicata
Adenovirus types 4 and 7 live and Fludarabine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
Cosa significa questa interazione in parole semplici
Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Fludarabine-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
Cosa fare
Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Fludarabine
- Fludarabine + Pentostatin Controindicata
- Belatacept + Fludarabine Maggiore
- Dengue vaccine + Fludarabine Maggiore
- Etrasimod + Fludarabine Maggiore
- Fingolimod + Fludarabine Maggiore
- Fludarabine + Ofatumumab sc Maggiore
Domande frequenti
Can I take Adenovirus types 4 and 7 live with Fludarabine?
MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Fludarabine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fludarabine causes profound and prolonged lymphopenia. A live oral adenovirus vaccine could replicate unchecked and cause disseminated vaccine-strain infection, and the vaccine response would also be poor.
How serious is the interaction between Adenovirus types 4 and 7 live and Fludarabine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give this live vaccine during fludarabine therapy. Defer vaccination until immune recovery is confirmed, usually at least 3 months after therapy ends.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Pentostatin, Belatacept, Dengue vaccine. The full list is on the Fludarabine page.
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