Interazioni tra farmaci
Adenovirus types 4 and 7 live + Paclitaxel
Gravità: Maggiore
Adenovirus types 4 and 7 live and Paclitaxel: major interaction.
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Sintesi
Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
Cosa significa questa interazione in parole semplici
Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Chemotherapy-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
Cosa fare
Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Paclitaxel
- Cobicistat + Paclitaxel Maggiore
- Cyclosporine + Paclitaxel Maggiore
- Cyclosporin + Paclitaxel Maggiore
- Deferiprone + Paclitaxel Maggiore
- Dengue vaccine + Paclitaxel Maggiore
- Doxorubicin + Paclitaxel Maggiore
Domande frequenti
Can I take Adenovirus types 4 and 7 live with Paclitaxel?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
How serious is the interaction between Adenovirus types 4 and 7 live and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Cobicistat, Cyclosporine, Cyclosporin. The full list is on the Paclitaxel page.
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