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Interazioni tra farmaci

Adenovirus types 4 and 7 live + Topotecan

Gravità: Controindicata

Adenovirus types 4 and 7 live and Topotecan: contraindicated interaction.

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Sintesi

Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.

Cosa significa questa interazione in parole semplici

Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Livello di evidenza: Moderate

Perché avviene

Cytotoxic immunosuppression impairs control of live attenuated virus replication and blunts vaccine-induced immunity.

Cosa fare

Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Adenovirus types 4 and 7 live with Topotecan?

MediHelp rates the interaction as contraindicated. Adenovirus types 4 and 7 live and Topotecan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Topotecan causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause infection. The vaccine response may also be inadequate.

How serious is the interaction between Adenovirus types 4 and 7 live and Topotecan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during chemotherapy. Defer vaccination until immune recovery, typically at least 3 months after stopping treatment, and consider non-live alternatives.

What other medicines interact with Topotecan?

MediHelp also lists interactions of Topotecan with, for example, Amiodarone, Cisplatin, Cobicistat. The full list is on the Topotecan page.

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