Interazioni tra farmaci
Alogliptin + Chlorpropamide
Gravità: Moderata
Alogliptin and Chlorpropamide: moderate interaction.
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Sintesi
Alogliptin alone rarely causes hypoglycemia, but with a sulfonylurea such as chlorpropamide the risk increases. Chlorpropamide's long duration can make hypoglycemia prolonged.
Cosa significa questa interazione in parole semplici
Alogliptin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Perché avviene
Additive glucose lowering from DPP-4 inhibition and sulfonylurea-stimulated insulin secretion.
Cosa fare
Consider reducing the chlorpropamide dose when alogliptin is started and monitor blood glucose for hypoglycemia.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Chlorpropamide
Altre interazioni di Alogliptin
- Alogliptin + Amlodipine-benazepril Moderata
- Alogliptin + Benazepril Moderata
- Alogliptin + Captopril Moderata
- Alogliptin + Captopril-hydrochlorothiazide Moderata
- Alogliptin + Dulaglutide Moderata
- Alogliptin + Gliclazide Moderata
Domande frequenti
Can I take Alogliptin with Chlorpropamide?
MediHelp rates the interaction as moderate. Alogliptin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alogliptin alone rarely causes hypoglycemia, but with a sulfonylurea such as chlorpropamide the risk increases. Chlorpropamide's long duration can make hypoglycemia prolonged.
How serious is the interaction between Alogliptin and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when alogliptin is started and monitor blood glucose for hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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