Interazioni tra farmaci
Alogliptin-pioglitazone + Cholic acid
Gravità: Moderata
Alogliptin-pioglitazone and Cholic acid: moderate interaction.
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Sintesi
Pioglitazone may inhibit the bile salt export pump, which could promote accumulation of conjugated bile salts in hepatocytes when given with cholic acid. This could contribute to liver injury, and pioglitazone itself carries hepatic warnings.
Cosa significa questa interazione in parole semplici
Alogliptin-pioglitazone and Cholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Cholic acid belongs to Gastrointestinal Tract.
Perché avviene
Possible inhibition of BSEP-mediated bile salt efflux reduces biliary elimination of bile acids.
Cosa fare
Monitor serum transaminases and bilirubin during co-therapy and stop cholic acid or reassess therapy if liver injury develops.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Domande frequenti
Can I take Alogliptin-pioglitazone with Cholic acid?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Cholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone may inhibit the bile salt export pump, which could promote accumulation of conjugated bile salts in hepatocytes when given with cholic acid. This could contribute to liver injury, and pioglitazone itself carries hepatic warnings.
How serious is the interaction between Alogliptin-pioglitazone and Cholic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin during co-therapy and stop cholic acid or reassess therapy if liver injury develops.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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