Interazioni tra farmaci
Alpelisib + Chlorpropamide
Gravità: Moderata
Alpelisib and Chlorpropamide: moderate interaction.
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Sintesi
Alpelisib may induce CYP2C9, which could lower exposure to CYP2C9 substrates and weaken their effect. However, alpelisib itself causes hyperglycemia, so glycemic control may worsen with chlorpropamide through both mechanisms.
Cosa significa questa interazione in parole semplici
Alpelisib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alpelisib belongs to Oncology; Chlorpropamide belongs to Endocrine.
Perché avviene
Alpelisib may induce CYP2C9 and also inhibits PI3K signaling, causing hyperglycemia that opposes the sulfonylurea.
Cosa fare
Monitor blood glucose closely during alpelisib treatment. Increase the antidiabetic regimen as needed.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Chlorpropamide
Altre interazioni di Alpelisib
- Alpelisib + Carbamazepine Maggiore
- Alpelisib + Phenytoin Maggiore
- Alpelisib + Secobarbital Maggiore
- Alpelisib + Apalutamide Moderata
- Alpelisib + Bosentan Moderata
- Alpelisib + Cyclosporin Moderata
Domande frequenti
Can I take Alpelisib with Chlorpropamide?
MediHelp rates the interaction as moderate. Alpelisib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alpelisib may induce CYP2C9, which could lower exposure to CYP2C9 substrates and weaken their effect. However, alpelisib itself causes hyperglycemia, so glycemic control may worsen with chlorpropamide through both mechanisms.
How serious is the interaction between Alpelisib and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during alpelisib treatment. Increase the antidiabetic regimen as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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