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Interazioni tra farmaci

Amikacin + Atracurium

Gravità: Maggiore

Amikacin and Atracurium: major interaction.

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Sintesi

Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.

Cosa significa questa interazione in parole semplici

Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amikacin belongs to Anti Bacterial; Atracurium belongs to Musculoskeletal.

Livello di evidenza: High

Perché avviene

Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity, additive to nondepolarising blockade.

Cosa fare

Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Amikacin with Atracurium?

MediHelp rates the interaction as major. Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.

How serious is the interaction between Amikacin and Atracurium?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.

What other medicines interact with Atracurium?

MediHelp also lists interactions of Atracurium with, for example, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen, Capreomycin. The full list is on the Atracurium page.

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