Interazioni tra farmaci
Amitriptyline + Methylene blue
Gravità: Controindicata
Amitriptyline and Methylene blue: contraindicated interaction.
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Sintesi
Methylene blue inhibits MAO-A and, with a serotonergic tricyclic such as amitriptyline, can precipitate serotonin syndrome. This has been reported with other serotonergic antidepressants and the risk is labelled.
Cosa significa questa interazione in parole semplici
Amitriptyline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
MAO-A inhibition by methylene blue combined with serotonin reuptake inhibition by amitriptyline.
Cosa fare
Avoid the combination in non-emergency settings. If urgent methylene blue treatment is essential, stop amitriptyline and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Amitriptyline
- Amitriptyline + Isocarboxazid Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amitriptyline + Pimozide Controindicata
- Amitriptyline + Procarbazine Controindicata
- Amitriptyline + Safinamide Controindicata
- Amitriptyline + Selegiline Controindicata
Domande frequenti
Can I take Amitriptyline with Methylene blue?
MediHelp rates the interaction as contraindicated. Amitriptyline and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with a serotonergic tricyclic such as amitriptyline, can precipitate serotonin syndrome. This has been reported with other serotonergic antidepressants and the risk is labelled.
How serious is the interaction between Amitriptyline and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in non-emergency settings. If urgent methylene blue treatment is essential, stop amitriptyline and monitor for serotonin toxicity for up to 2 weeks or until 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Amitriptyline page.
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