Interazioni tra farmaci
Artemether / lumefantrine + Ofloxacin
Gravità: Maggiore
Artemether / lumefantrine and Ofloxacin: major interaction.
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Sintesi
Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
Cosa significa questa interazione in parole semplici
Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive hERG potassium channel blockade leading to QT prolongation.
Cosa fare
Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Ofloxacin
- Ofloxacin + Thioridazine Controindicata
- Adagrasib + Ofloxacin Maggiore
- Amiodarone + Ofloxacin Maggiore
- Amisulpride + Ofloxacin Maggiore
- Anagrelide + Ofloxacin Maggiore
- Arsenic trioxide + Ofloxacin Maggiore
Domande frequenti
Can I take Artemether / lumefantrine with Ofloxacin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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