Interazioni tra farmaci
Azilsartan-chlorthalidone + Bretylium
Gravità: Maggiore
Azilsartan-chlorthalidone and Bretylium: major interaction.
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Sintesi
Bretylium frequently causes hypotension by blocking norepinephrine release from sympathetic nerve terminals. Combined with an ARB and a thiazide-like diuretic, hypotension may be more severe and prolonged.
Cosa significa questa interazione in parole semplici
Azilsartan-chlorthalidone and Bretylium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive hypotension from adrenergic neuron blockade plus renin-angiotensin blockade and diuresis.
Cosa fare
Monitor blood pressure closely and consider holding or reducing antihypertensives while bretylium is given. Correct volume depletion and be ready to give fluids if hypotension occurs.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Azilsartan-chlorthalidone
- Aliskiren + Azilsartan-chlorthalidone Controindicata
- Azilsartan-chlorthalidone + Sparsentan Controindicata
- Aceclofenac + Azilsartan-chlorthalidone Maggiore
- Aldesleukin + Azilsartan-chlorthalidone Maggiore
- Amifostine + Azilsartan-chlorthalidone Maggiore
- Azilsartan-chlorthalidone + Benazepril Maggiore
Domande frequenti
Can I take Azilsartan-chlorthalidone with Bretylium?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Bretylium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bretylium frequently causes hypotension by blocking norepinephrine release from sympathetic nerve terminals. Combined with an ARB and a thiazide-like diuretic, hypotension may be more severe and prolonged.
How serious is the interaction between Azilsartan-chlorthalidone and Bretylium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider holding or reducing antihypertensives while bretylium is given. Correct volume depletion and be ready to give fluids if hypotension occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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