Interazioni tra farmaci
Azithromycin + Pimozide
Gravità: Controindicata
Azithromycin and Pimozide: contraindicated interaction.
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Sintesi
Azithromycin can prolong the QT interval, and pimozide is a drug with a narrow margin in which QT lengthening and torsades have occurred. Azithromycin is a weaker CYP3A4 inhibitor than other macrolides, but the pharmacodynamic risk remains.
Cosa significa questa interazione in parole semplici
Azithromycin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azithromycin belongs to Anti Bacterial; Pimozide belongs to Central Nervous System.
Perché avviene
Additive QTc prolongation
Cosa fare
Avoid; use a non-QT-prolonging antibiotic during pimozide therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Azithromycin
- Azithromycin + Cisapride Controindicata
- Azithromycin + Domperidone Controindicata
- Azithromycin + Dronedarone Controindicata
- Azithromycin + Piperaquine Controindicata
- Azithromycin + Thioridazine Controindicata
- Adagrasib + Azithromycin Maggiore
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Azithromycin with Pimozide?
MediHelp rates the interaction as contraindicated. Azithromycin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Azithromycin can prolong the QT interval, and pimozide is a drug with a narrow margin in which QT lengthening and torsades have occurred. Azithromycin is a weaker CYP3A4 inhibitor than other macrolides, but the pharmacodynamic risk remains.
How serious is the interaction between Azithromycin and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use a non-QT-prolonging antibiotic during pimozide therapy.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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