Interazioni tra farmaci
Bcg vaccine live + Chloramphenicol
Gravità: Maggiore
Bcg vaccine live and Chloramphenicol: major interaction.
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Sintesi
Chloramphenicol is active against many bacteria and may reduce the replication of the live attenuated bacteria in the vaccine. This can lead to a weaker immune response and reduced protection.
Cosa significa questa interazione in parole semplici
Bcg vaccine live and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Antibacterial activity of chloramphenicol may inhibit the live attenuated bacterial vaccine strain, reducing immunogenicity.
Cosa fare
Defer the live BCG vaccination until the chloramphenicol course is finished, allowing an adequate washout interval. Revaccinate if the vaccine was given during antibiotic therapy.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Chloramphenicol
- Adagrasib + Chloramphenicol Maggiore
- Avapritinib + Chloramphenicol Maggiore
- Benzhydrocodone / acetaminophen + Chloramphenicol Maggiore
- Chloramphenicol + Cobimetinib Maggiore
- Chloramphenicol + Colchicine Maggiore
- Chloramphenicol + Conivaptan Maggiore
Domande frequenti
Can I take Bcg vaccine live with Chloramphenicol?
MediHelp rates the interaction as major. Bcg vaccine live and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol is active against many bacteria and may reduce the replication of the live attenuated bacteria in the vaccine. This can lead to a weaker immune response and reduced protection.
How serious is the interaction between Bcg vaccine live and Chloramphenicol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer the live BCG vaccination until the chloramphenicol course is finished, allowing an adequate washout interval. Revaccinate if the vaccine was given during antibiotic therapy.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Benzhydrocodone / acetaminophen. The full list is on the Chloramphenicol page.
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