Interazioni tra farmaci
Benzhydrocodone / acetaminophen + Cetirizine
Gravità: Moderata
Benzhydrocodone / acetaminophen and Cetirizine: moderate interaction.
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Sintesi
Benzhydrocodone is an opioid prodrug of hydrocodone, and opioids combined with sedating antihistamines can add to drowsiness and, less commonly, respiratory depression. Cetirizine is less sedating than older antihistamines, so the effect is usually modest.
Cosa significa questa interazione in parole semplici
Benzhydrocodone / acetaminophen and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Additive CNS depression from opioid mu-receptor agonism and H1 antagonism.
Cosa fare
Use the lowest effective opioid dose and monitor for sedation and slowed breathing, especially when starting therapy or raising doses. Counsel patients against alcohol and driving.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Domande frequenti
Can I take Benzhydrocodone / acetaminophen with Cetirizine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is an opioid prodrug of hydrocodone, and opioids combined with sedating antihistamines can add to drowsiness and, less commonly, respiratory depression. Cetirizine is less sedating than older antihistamines, so the effect is usually modest.
How serious is the interaction between Benzhydrocodone / acetaminophen and Cetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and slowed breathing, especially when starting therapy or raising doses. Counsel patients against alcohol and driving.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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