Interazioni tra farmaci
Bexagliflozin + Chlorpropamide
Gravità: Moderata
Bexagliflozin and Chlorpropamide: moderate interaction.
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Sintesi
SGLT2 inhibitors added to sulfonylureas increase the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
Cosa significa questa interazione in parole semplici
Bexagliflozin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Chlorpropamide belongs to Endocrine.
Perché avviene
Additive glucose lowering from insulin secretion by the sulfonylurea and urinary glucose excretion by bexagliflozin.
Cosa fare
Consider reducing the chlorpropamide dose when bexagliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Chlorpropamide
Altre interazioni di Bexagliflozin
- Bexagliflozin + Carbamazepine Moderata
- Bexagliflozin + Gliclazide Moderata
- Bexagliflozin + Glimepiride Moderata
- Bexagliflozin + Glimepiride-pioglitazone Moderata
- Bexagliflozin + Glipizide Moderata
- Bexagliflozin + Glipizide-metformin Moderata
Domande frequenti
Can I take Bexagliflozin with Chlorpropamide?
MediHelp rates the interaction as moderate. Bexagliflozin and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors added to sulfonylureas increase the risk of hypoglycemia. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Bexagliflozin and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when bexagliflozin is started. Monitor blood glucose and counsel the patient on hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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