Interazioni tra farmaci
Bexarotene + Gemfibrozil
Gravità: Maggiore
Bexarotene and Gemfibrozil: major interaction.
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Sintesi
Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
Cosa significa questa interazione in parole semplici
Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bexarotene belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
Perché avviene
Proposed inhibition of CYP3A4-mediated and possibly other metabolic clearance of bexarotene by gemfibrozil; the mechanism is not firmly established.
Cosa fare
Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Gemfibrozil
- Daprodustat + Gemfibrozil Controindicata
- Elagolix + Gemfibrozil Controindicata
- Gemfibrozil + Mavacamten Controindicata
- Gemfibrozil + Metformin-repaglinide Controindicata
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Controindicata
- Gemfibrozil + Repaglinide Controindicata
Altre interazioni di Bexarotene
- Bexarotene + Lorlatinib Maggiore
- Alogliptin-pioglitazone + Bexarotene Moderata
- Amobarbital + Bexarotene Moderata
- Aprepitant + Bexarotene Moderata
- Axitinib + Bexarotene Moderata
- Bexarotene + Bosentan Moderata
Domande frequenti
Can I take Bexarotene with Gemfibrozil?
MediHelp rates the interaction as major. Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
How serious is the interaction between Bexarotene and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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