Interazioni tra farmaci
Brompheniramine + Dextromoramide
Gravità: Maggiore
Brompheniramine and Dextromoramide: major interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Dextromoramide is a potent opioid, and combining it with a sedating antihistamine increases the risk of profound sedation and respiratory depression. The effect is most pronounced in elderly or frail patients.
Cosa significa questa interazione in parole semplici
Brompheniramine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS and respiratory depression via opioid agonism and H1 antagonism.
Cosa fare
Avoid if possible and use a non-sedating antihistamine. If combined, use the lowest doses and monitor respiratory rate and sedation closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Riferimenti
Altre interazioni di Brompheniramine
Domande frequenti
Can I take Brompheniramine with Dextromoramide?
MediHelp rates the interaction as major. Brompheniramine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and combining it with a sedating antihistamine increases the risk of profound sedation and respiratory depression. The effect is most pronounced in elderly or frail patients.
How serious is the interaction between Brompheniramine and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use a non-sedating antihistamine. If combined, use the lowest doses and monitor respiratory rate and sedation closely.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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