Interazioni tra farmaci
Buprenorphine long-acting + Chlorpheniramine
Gravità: Maggiore
Buprenorphine long-acting and Chlorpheniramine: major interaction.
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Sintesi
Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
Cosa significa questa interazione in parole semplici
Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS depression from an opioid and a sedating antihistamine.
Cosa fare
Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Chlorpheniramine
- Belladonna and opium + Chlorpheniramine Maggiore
- Benzhydrocodone / acetaminophen + Chlorpheniramine Maggiore
- Brexanolone + Chlorpheniramine Maggiore
- Buprenorphine subdermal implant + Chlorpheniramine Maggiore
- Buprenorphine transdermal + Chlorpheniramine Maggiore
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine Maggiore
Domande frequenti
Can I take Buprenorphine long-acting with Chlorpheniramine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpheniramine adds sedation to buprenorphine, increasing the risk of drowsiness and respiratory depression. The long-acting injection depot cannot be quickly removed.
How serious is the interaction between Buprenorphine long-acting and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If combined, limit dose and duration of chlorpheniramine and monitor for sedation and respiratory depression.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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