Interazioni tra farmaci
Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate
Gravità: Controindicata
Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate: contraindicated interaction.
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Sintesi
Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
Cosa significa questa interazione in parole semplici
Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive CNS and respiratory depression through pharmacodynamic synergism (GABAergic sedative plus GHB-receptor and GABA-B agonism).
Cosa fare
Do not combine; stop chloral hydrate or use a non-sedating alternative before starting oxybate therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Chloral hydrate
- Chloral hydrate + Sodium oxybate Controindicata
- Alfentanil + Chloral hydrate Maggiore
- Alprazolam + Chloral hydrate Maggiore
- Amobarbital + Chloral hydrate Maggiore
- Belladonna and opium + Chloral hydrate Maggiore
- Benzhydrocodone / acetaminophen + Chloral hydrate Maggiore
Domande frequenti
Can I take Calcium / magnesium / potassium / sodium oxybates with Chloral hydrate?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents depress the central nervous system, and together they can cause profound sedation, respiratory depression, coma, or death. Oxybate labeling prohibits use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Chloral hydrate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop chloral hydrate or use a non-sedating alternative before starting oxybate therapy.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Chloral hydrate page.
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