Interazioni tra farmaci
Carbamazepine + Lorlatinib
Gravità: Controindicata
Carbamazepine and Lorlatinib: contraindicated interaction.
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Sintesi
Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lorlatinib. The result is reduced lorlatinib exposure and loss of tumour control; strong inducers have also provoked marked transaminase elevation.
Cosa significa questa interazione in parole semplici
Carbamazepine and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Perché avviene
Enzyme induction by carbamazepine increases metabolic clearance of lorlatinib
Cosa fare
Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lorlatinib.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Carbamazepine
- Artemether / lumefantrine + Carbamazepine Controindicata
- Cabotegravir + Carbamazepine Controindicata
- Carbamazepine + Delamanid Controindicata
- Carbamazepine + Dienogest / estradiol valerate Controindicata
- Carbamazepine + Doravirine Controindicata
- Carbamazepine + Elbasvir / grazoprevir Controindicata
Altre interazioni di Lorlatinib
- Amobarbital + Lorlatinib Controindicata
- Apalutamide + Lorlatinib Controindicata
- Butabarbital + Lorlatinib Controindicata
- Enzalutamide + Lorlatinib Controindicata
- Fosphenytoin + Lorlatinib Controindicata
- Lonafarnib + Lorlatinib Controindicata
Domande frequenti
Can I take Carbamazepine with Lorlatinib?
MediHelp rates the interaction as contraindicated. Carbamazepine and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lorlatinib. The result is reduced lorlatinib exposure and loss of tumour control; strong inducers have also provoked marked transaminase elevation.
How serious is the interaction between Carbamazepine and Lorlatinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lorlatinib.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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