Interazioni tra farmaci
Carbamazepine + Mavacamten
Gravità: Controindicata
Carbamazepine and Mavacamten: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Carbamazepine markedly reduces mavacamten exposure, which may cause loss of efficacy in obstructive hypertrophic cardiomyopathy. Stopping the inducer later could also cause mavacamten levels to rise unexpectedly.
Cosa significa questa interazione in parole semplici
Carbamazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Perché avviene
Carbamazepine induces CYP2C19 and CYP3A4, the main enzymes clearing mavacamten.
Cosa fare
Avoid the combination as labeled. If an inducer is stopped or started, reassess LVEF and gradients and adjust mavacamten dose by echocardiography.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Carbamazepine e Mavacamten, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Carbamazepine
- Artemether / lumefantrine + Carbamazepine Controindicata
- Cabotegravir + Carbamazepine Controindicata
- Carbamazepine + Delamanid Controindicata
- Carbamazepine + Dienogest / estradiol valerate Controindicata
- Carbamazepine + Doravirine Controindicata
- Carbamazepine + Elbasvir / grazoprevir Controindicata
Altre interazioni di Mavacamten
- Apalutamide + Mavacamten Controindicata
- Clarithromycin + Mavacamten Controindicata
- Dexlansoprazole + Mavacamten Controindicata
- Efavirenz + Mavacamten Controindicata
- Enzalutamide + Mavacamten Controindicata
- Eslicarbazepine + Mavacamten Controindicata
Domande frequenti
Can I take Carbamazepine with Mavacamten?
MediHelp rates the interaction as contraindicated. Carbamazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly reduces mavacamten exposure, which may cause loss of efficacy in obstructive hypertrophic cardiomyopathy. Stopping the inducer later could also cause mavacamten levels to rise unexpectedly.
How serious is the interaction between Carbamazepine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as labeled. If an inducer is stopped or started, reassess LVEF and gradients and adjust mavacamten dose by echocardiography.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
