Interazioni tra farmaci
Carbidopa-levodopa + Phenelzine
Gravità: Controindicata
Carbidopa-levodopa and Phenelzine: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
Cosa significa questa interazione in parole semplici
Carbidopa-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-levodopa belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines
Cosa fare
Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Carbidopa-levodopa e Phenelzine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Controindicata
- Carbidopa-levodopa + Selegiline transdermal Controindicata
- Carbidopa-levodopa + Tranylcypromine Controindicata
- Amisulpride + Carbidopa-levodopa Maggiore
- Asenapine + Carbidopa-levodopa Maggiore
- Carbidopa-levodopa + Chlorpromazine Maggiore
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Carbidopa-levodopa with Phenelzine?
MediHelp rates the interaction as contraindicated. Carbidopa-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-levodopa and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-levodopa page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
