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Interazioni tra farmaci

Cisatracurium + Clindamycin

Gravità: Maggiore

Cisatracurium and Clindamycin: major interaction.

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Sintesi

Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by non-depolarizing blockers such as cisatracurium. This may delay recovery of spontaneous breathing and cause postoperative respiratory depression.

Cosa significa questa interazione in parole semplici

Cisatracurium and Clindamycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisatracurium belongs to Musculoskeletal; Clindamycin belongs to Anti Bacterial.

Livello di evidenza: Moderate

Perché avviene

Additive neuromuscular blockade through presynaptic and postsynaptic inhibition of neuromuscular transmission by clindamycin.

Cosa fare

Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Ensure ventilatory support and recovery of neuromuscular function before extubation.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cisatracurium with Clindamycin?

MediHelp rates the interaction as major. Cisatracurium and Clindamycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by non-depolarizing blockers such as cisatracurium. This may delay recovery of spontaneous breathing and cause postoperative respiratory depression.

How serious is the interaction between Cisatracurium and Clindamycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and titrate cisatracurium to effect. Ensure ventilatory support and recovery of neuromuscular function before extubation.

What other medicines interact with Cisatracurium?

MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.

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