Interazioni tra farmaci
Citalopram + Pimozide
Gravità: Controindicata
Citalopram and Pimozide: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
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Sintesi
Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
Cosa significa questa interazione in parole semplici
Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Citalopram belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Perché avviene
Additive QT prolongation. Citalopram is also partly metabolized by CYP2D6 and CYP3A4, and pimozide is a CYP2D6 and CYP3A4 substrate, so pharmacokinetic effects may add to this.
Cosa fare
Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Riferimenti
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Altre interazioni di Citalopram
- Cisapride + Citalopram Controindicata
- Citalopram + Dronedarone Controindicata
- Citalopram + Escitalopram Controindicata
- Citalopram + Isocarboxazid Controindicata
- Citalopram + Methylene blue Controindicata
- Citalopram + Phenelzine Controindicata
Domande frequenti
Can I take Citalopram with Pimozide?
MediHelp rates the interaction as contraindicated. Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
How serious is the interaction between Citalopram and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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