Interazioni tra farmaci
Conivaptan + Ketoconazole
Gravità: Controindicata
Conivaptan and Ketoconazole: contraindicated interaction.
Ultimo aggiornamento Fonti: US FDA label
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
Cosa significa questa interazione in parole semplici
Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Ketoconazole is a strong CYP3A4 inhibitor, and conivaptan is a CYP3A4 substrate, so clearance falls and exposure increases.
Cosa fare
Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Conivaptan e Ketoconazole, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Riferimenti
Altre interazioni di Ketoconazole
- Alfuzosin + Ketoconazole Controindicata
- Alprazolam + Ketoconazole Controindicata
- Avanafil + Ketoconazole Controindicata
- Dihydroergotamine intranasal + Ketoconazole Controindicata
- Dihydroergotamine + Ketoconazole Controindicata
- Disopyramide + Ketoconazole Controindicata
Domande frequenti
Can I take Conivaptan with Ketoconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
How serious is the interaction between Conivaptan and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
