Interazioni tra farmaci
Desipramine + Phenelzine
Gravità: Controindicata
Desipramine and Phenelzine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Cosa significa questa interazione in parole semplici
Desipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
Cosa fare
Do not combine; allow at least 14 days after stopping the phenelzine before starting desipramine, and at least 14 days after stopping desipramine before starting the phenelzine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Desipramine
- Desipramine + Disopyramide Controindicata
- Desipramine + Dofetilide Controindicata
- Desipramine + Ibutilide Controindicata
- Desipramine + Isocarboxazid Controindicata
- Desipramine + Methylene blue Controindicata
- Desipramine + Pentamidine Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Desipramine with Phenelzine?
MediHelp rates the interaction as contraindicated. Desipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the phenelzine before starting desipramine, and at least 14 days after stopping desipramine before starting the phenelzine.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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