Interazioni tra farmaci
Desipramine + Umeclidinium-vilanterol
Gravità: Maggiore
Desipramine and Umeclidinium-vilanterol: major interaction.
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Sintesi
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, leading to tachycardia, hypertension and arrhythmias. Desipramine also has QT-prolonging potential.
Cosa significa questa interazione in parole semplici
Desipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Perché avviene
Additive adrenergic cardiovascular stimulation and QT prolongation.
Cosa fare
Avoid the combination if possible, or monitor heart rate, blood pressure and ECG closely. Consider a different class of long-acting bronchodilator or antidepressant in patients with heart disease.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Umeclidinium-vilanterol
Altre interazioni di Desipramine
- Desipramine + Disopyramide Controindicata
- Desipramine + Dofetilide Controindicata
- Desipramine + Ibutilide Controindicata
- Desipramine + Isocarboxazid Controindicata
- Desipramine + Methylene blue Controindicata
- Desipramine + Pentamidine Controindicata
Domande frequenti
Can I take Desipramine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Desipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists such as vilanterol, leading to tachycardia, hypertension and arrhythmias. Desipramine also has QT-prolonging potential.
How serious is the interaction between Desipramine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor heart rate, blood pressure and ECG closely. Consider a different class of long-acting bronchodilator or antidepressant in patients with heart disease.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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