Interazioni tra farmaci
Diatrizoate meglumine / diatrizoate + Glyburide-metformin
Gravità: Maggiore
Diatrizoate meglumine / diatrizoate and Glyburide-metformin: major interaction.
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Sintesi
Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
Cosa significa questa interazione in parole semplici
Diatrizoate meglumine / diatrizoate and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Contrast-induced decline in renal function reduces metformin elimination and raises the risk of lactic acidosis.
Cosa fare
Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease or intra-arterial studies. Restart after 48 hours only once renal function is confirmed stable.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Glyburide-metformin
- Bosentan + Glyburide-metformin Controindicata
- Cholic acid + Glyburide-metformin Maggiore
- Clarithromycin + Glyburide-metformin Maggiore
- Contrast media + Glyburide-metformin Maggiore
- Diatrizoate + Glyburide-metformin Maggiore
- Diazoxide + Glyburide-metformin Maggiore
Domande frequenti
Can I take Diatrizoate meglumine / diatrizoate with Glyburide-metformin?
MediHelp rates the interaction as major. Diatrizoate meglumine / diatrizoate and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which reduces metformin clearance and may lead to metformin accumulation and lactic acidosis. The risk is greatest with impaired renal function or intra-arterial administration.
How serious is the interaction between Diatrizoate meglumine / diatrizoate and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before contrast in patients with eGFR below 30, liver disease or intra-arterial studies. Restart after 48 hours only once renal function is confirmed stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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