Interazioni tra farmaci
Efavirenz + Isavuconazole
Gravità: Controindicata
Efavirenz and Isavuconazole: contraindicated interaction.
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Sintesi
Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
Cosa significa questa interazione in parole semplici
Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Efavirenz belongs to Anti Virals; Isavuconazole belongs to Anti Fungals.
Perché avviene
Efavirenz induces CYP3A4/5, accelerating isavuconazole metabolism.
Cosa fare
Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Isavuconazole
- Carbamazepine + Isavuconazole Controindicata
- Etravirine + Isavuconazole Controindicata
- Isavuconazole + Ketoconazole Controindicata
- Isavuconazole + Phenobarbitone Controindicata
- Isavuconazole + Phenytoin Controindicata
- Isavuconazole + Rifampicin Controindicata
Altre interazioni di Efavirenz
- Cobimetinib + Efavirenz Controindicata
- Dienogest / estradiol valerate + Efavirenz Controindicata
- Dihydroergotamine intranasal + Efavirenz Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Doravirine + Efavirenz Controindicata
- Efavirenz + Elbasvir / grazoprevir Controindicata
Domande frequenti
Can I take Efavirenz with Isavuconazole?
MediHelp rates the interaction as contraindicated. Efavirenz and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Efavirenz is a moderate CYP3A4 inducer and may lower isavuconazole exposure, compromising antifungal efficacy. Isavuconazole could also alter efavirenz concentrations.
How serious is the interaction between Efavirenz and Isavuconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and use an alternative antiretroviral such as an integrase inhibitor-based regimen if feasible. If combined, monitor isavuconazole levels and clinical response.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Etravirine, Ketoconazole. The full list is on the Isavuconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
