Interazioni tra farmaci
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir
Gravità: Moderata
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir: moderate interaction.
Ultimo aggiornamento
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Sintesi
Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
Cosa significa questa interazione in parole semplici
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Competition for renal tubular secretion and additive renal burden, which can decrease clearance of each drug.
Cosa fare
Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Entecavir
- Alogliptin-metformin + Entecavir Moderata
- Canagliflozin-metformin + Entecavir Moderata
- Cidofovir + Entecavir Moderata
- Cyclosporine + Entecavir Moderata
- Dapagliflozin-metformin + Entecavir Moderata
- Empagliflozin-metformin + Entecavir Moderata
Domande frequenti
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Entecavir?
MediHelp rates the interaction as moderate. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entecavir, emtricitabine and tenofovir are all eliminated by the kidney through filtration and active tubular secretion, and cobicistat can raise serum creatinine by inhibiting tubular secretion. Concurrent use may increase concentrations of the renally cleared drugs and the risk of renal adverse events. Entecavir is sometimes combined with tenofovir regimens in hepatitis B coinfection.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Entecavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated clearance and phosphate regularly. Adjust the entecavir dose if creatinine clearance falls.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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