Interazioni tra farmaci
Epinephrine + Phenelzine
Gravità: Controindicata
Epinephrine and Phenelzine: contraindicated interaction.
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Sintesi
Epinephrine is partly cleared by MAO and COMT, and phenelzine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
Cosa significa questa interazione in parole semplici
Epinephrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Epinephrine belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Perché avviene
MAO inhibition potentiating sympathomimetic effects
Cosa fare
Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Altre interazioni di Epinephrine
- Epinephrine + Isocarboxazid Controindicata
- Epinephrine + Tranylcypromine Controindicata
- Acebutolol + Epinephrine Maggiore
- Amitriptyline + Epinephrine Maggiore
- Amoxapine + Epinephrine Maggiore
- Atenolol-chlorthalidone + Epinephrine Maggiore
Domande frequenti
Can I take Epinephrine with Phenelzine?
MediHelp rates the interaction as contraindicated. Epinephrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Epinephrine is partly cleared by MAO and COMT, and phenelzine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
How serious is the interaction between Epinephrine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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