Interazioni tra farmaci
Escitalopram + Phenelzine
Gravità: Controindicata
Escitalopram and Phenelzine: contraindicated interaction.
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Sintesi
Phenelzine irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
Cosa significa questa interazione in parole semplici
Escitalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Escitalopram belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Perché avviene
Inhibition of monoamine oxidase combined with an SSRI activity leading to excess serotonergic stimulation
Cosa fare
Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Escitalopram
- Cisapride + Escitalopram Controindicata
- Citalopram + Escitalopram Controindicata
- Escitalopram + Isocarboxazid Controindicata
- Escitalopram + Methylene blue Controindicata
- Escitalopram + Pimozide Controindicata
- Escitalopram + Procarbazine Controindicata
Altre interazioni di Phenelzine
- 5-HTP + Phenelzine Controindicata
- Amitriptyline + Phenelzine Controindicata
- Amoxapine + Phenelzine Controindicata
- Atomoxetine + Phenelzine Controindicata
- Benzphetamine + Phenelzine Controindicata
- Brimonidine + Phenelzine Controindicata
Domande frequenti
Can I take Escitalopram with Phenelzine?
MediHelp rates the interaction as contraindicated. Escitalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.
How serious is the interaction between Escitalopram and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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