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Interazioni tra farmaci

Etoposide + Pentostatin

Gravità: Controindicata

Etoposide and Pentostatin: contraindicated interaction.

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Sintesi

In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.

Cosa significa questa interazione in parole semplici

Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Etoposide belongs to Oncology; Pentostatin belongs to Oncology.

Livello di evidenza: Moderate

Perché avviene

Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.

Cosa fare

Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Etoposide with Pentostatin?

MediHelp rates the interaction as contraindicated. Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.

How serious is the interaction between Etoposide and Pentostatin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.

What other medicines interact with Pentostatin?

MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.

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