Interazioni tra farmaci
Factor viii + Marstacimab
Gravità: Maggiore
Factor viii and Marstacimab: major interaction.
Ultimo aggiornamento
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Sintesi
Marstacimab inhibits tissue factor pathway inhibitor and raises hemostatic potential, and adding factor VIII concentrates may further increase the risk of thromboembolic events. Factor VIII used for prophylaxis should be discontinued before starting marstacimab.
Cosa significa questa interazione in parole semplici
Factor viii and Marstacimab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Factor viii belongs to Cardiovascular; Marstacimab belongs to Cardiovascular.
Perché avviene
Additive procoagulant pharmacodynamic effects of TFPI inhibition and exogenous factor VIII.
Cosa fare
Stop factor VIII prophylaxis before starting marstacimab, and use the lowest effective factor VIII dose only for breakthrough bleeds. Monitor for signs of thrombosis.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Factor viii
- Concizumab + Factor viii Maggiore
Domande frequenti
Can I take Factor viii with Marstacimab?
MediHelp rates the interaction as major. Factor viii and Marstacimab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Marstacimab inhibits tissue factor pathway inhibitor and raises hemostatic potential, and adding factor VIII concentrates may further increase the risk of thromboembolic events. Factor VIII used for prophylaxis should be discontinued before starting marstacimab.
How serious is the interaction between Factor viii and Marstacimab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop factor VIII prophylaxis before starting marstacimab, and use the lowest effective factor VIII dose only for breakthrough bleeds. Monitor for signs of thrombosis.
What other medicines interact with Factor viii?
MediHelp also lists interactions of Factor viii with, for example, Concizumab. The full list is on the Factor viii page.
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