Interazioni tra farmaci
Haloperidol + Pimozide
Gravità: Controindicata
Haloperidol and Pimozide: contraindicated interaction.
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Sintesi
Haloperidol blocks hERG channels and carries a recognised dose-related QTc and torsades de pointes risk, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
Cosa significa questa interazione in parole semplici
Haloperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Haloperidol belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Perché avviene
Additive blockade of cardiac repolarising potassium currents (hERG)
Cosa fare
Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Haloperidol
- Dofetilide + Haloperidol Controindicata
- Dronedarone + Haloperidol Controindicata
- Haloperidol + Ibutilide Controindicata
- Haloperidol + Levoketoconazole Controindicata
- Haloperidol + Panobinostat Controindicata
- Haloperidol + Ziprasidone Controindicata
Altre interazioni di Pimozide
- Adagrasib + Pimozide Controindicata
- Amiodarone + Pimozide Controindicata
- Amisulpride + Pimozide Controindicata
- Amitriptyline + Pimozide Controindicata
- Amoxapine + Pimozide Controindicata
- Anagrelide + Pimozide Controindicata
Domande frequenti
Can I take Haloperidol with Pimozide?
MediHelp rates the interaction as contraindicated. Haloperidol and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Haloperidol blocks hERG channels and carries a recognised dose-related QTc and torsades de pointes risk, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Haloperidol and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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