Interazioni tra farmaci
Indomethacin + Ketorolac intranasal
Gravità: Controindicata
Indomethacin and Ketorolac intranasal: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
Cosa significa questa interazione in parole semplici
Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
Cosa fare
Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Indomethacin
- Indomethacin + Ketorolac Controindicata
- Aceclofenac + Indomethacin Maggiore
- Acemetacin + Indomethacin Maggiore
- Acetylsalicylic acid + Indomethacin Maggiore
- Alteplase + Indomethacin Maggiore
- Amiloride + Indomethacin Maggiore
Domande frequenti
Can I take Indomethacin with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
How serious is the interaction between Indomethacin and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Indomethacin page.
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