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Interazioni tra farmaci

Pimavanserin + Pimozide

Gravità: Controindicata

Pimavanserin and Pimozide: contraindicated interaction.

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Sintesi

Pimavanserin and pimozide both prolong the QT interval, increasing the chance of ventricular arrhythmias including torsades de pointes. Pimavanserin labeling advises against use with other QT-prolonging drugs.

Cosa significa questa interazione in parole semplici

Pimavanserin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Pimavanserin belongs to Central Nervous System; Pimozide belongs to Central Nervous System.

Livello di evidenza: Moderate

Perché avviene

Additive pharmacodynamic QT prolongation.

Cosa fare

Avoid the combination and choose an agent without QT effects. If treatment must overlap, monitor ECG and electrolytes closely.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Pimavanserin with Pimozide?

MediHelp rates the interaction as contraindicated. Pimavanserin and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimavanserin and pimozide both prolong the QT interval, increasing the chance of ventricular arrhythmias including torsades de pointes. Pimavanserin labeling advises against use with other QT-prolonging drugs.

How serious is the interaction between Pimavanserin and Pimozide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an agent without QT effects. If treatment must overlap, monitor ECG and electrolytes closely.

What other medicines interact with Pimozide?

MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.

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