医薬品リファレンス
Avelumab
Avelumab is a medicine in the class oncology. It is used for renal cell carcinoma.
- 薬効分類: Oncology
- 効能・効果: renal cell carcinoma
最終更新日 出典: EMA SmPC
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
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要点
- 薬効分類
- Oncology
- ATCコード
- L01FF04
- 一般的な剤形
- 注射剤
- 一般的な規格
- 20 mg/ml
- 既知の相互作用
- 5 (中等度: 4 · 軽度: 1)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Human IgG1 monoclonal antibody against PD-L1. It blocks PD-L1 interaction with PD-1 and B7.1 receptors, removing suppression of cytotoxic CD8+ T-cells and restoring anti-tumour T-cell responses. It also induces NK cell-mediated tumour cell lysis via ADCC.
成人の通常用量（添付文書の要約）
Monotherapy (MCC; first-line maintenance UC): 800 mg IV over 60 minutes every 2 weeks until disease progression or unacceptable toxicity
妊娠と授乳
- 妊娠
- Unsafe Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment.
- 授乳
- Unsafe Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
報告されている副作用
- Fatigue
- Nausea
- Diarrhoea
- Constipation
- Decreased appetite
- Infusion-related reactions
禁忌
- Hypersensitivity to the active substance or to any excipient
注意が必要な方
- Infusion-related reactions can be severe; monitor for pyrexia, chills, flushing, hypotension, dyspnoea, wheezing, back pain, abdominal pain and urticaria.
- Immune-mediated adverse reactions (pneumonitis, hepatitis, colitis, pancreatitis, myocarditis, endocrinopathies, nephritis) may be severe or fatal; monitor, withhold and give corticosteroids according to severity.
- With axitinib, hepatotoxicity occurs with higher frequency of Grade 3 and 4 ALT/AST elevation; monitor liver function more frequently than with monotherapy.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (5)
- Avelumab + Cefadroxil Moderate
- Avelumab + Cefalexin Moderate
- Avelumab + Piperacillin Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Avelumab + Penicillin g Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Avelumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Avelumab used for?
Avelumab is a medicine in the class oncology. It is used for Renal cell carcinoma.
What side effects have been reported with Avelumab?
Fatigue, Nausea, Diarrhoea, Constipation, Decreased appetite, Infusion-related reactions.
Can Avelumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Limited data; based on mechanism it could cause foetal harm including abortion or stillbirth. Not recommended during pregnancy unless the woman's condition requires treatment. Breastfeeding: Unsafe. Unknown if excreted in human milk; advised not to breast-feed during treatment and for at least 1 month after the last dose.
What does Avelumab interact with?
MediHelp lists 5 known interactions for Avelumab. Moderate: 4 · Minor: 1. The most serious include Cefadroxil, Cefalexin, Piperacillin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
