医薬品リファレンス
Burosumab
Burosumab is a medicine in the class miscellaneous. It is used for hypophosphatemia.
- 薬効分類: Miscellaneous
- 効能・効果: hypophosphatemia
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- M05BX05
- 一般的な剤形
- 注射剤
- 一般的な規格
- 10 mg/ml
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Burosumab-twza binds to and inhibits the biological activity of FGF23, restoring renal phosphate reabsorption and increasing serum 1,25 dihydroxy vitamin D.
成人の通常用量（添付文書の要約）
Adult XLH: starting 1 mg/kg rounded to nearest 10 mg, maximum 90 mg, subcutaneously every four weeks; may increase to 0.5 mg/kg (max 90 mg) every 2 weeks, then 1 mg/kg (max 90 mg) every 2 weeks if needed.
妊娠と授乳
- 妊娠
- Unknown No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy.
- 授乳
- Unknown No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
報告されている副作用
- Pyrexia
- Injection site reaction
- Cough
- Vomiting
- Headache
- Tooth abscess
禁忌
- Concomitant use with oral phosphate and/or active vitamin D analogs, due to risk of hyperphosphatemia.
- When serum phosphorus is within or above the normal range for age.
- Severe renal impairment or end stage renal disease.
注意が必要な方
- Hypersensitivity reactions (rash, urticaria) reported; discontinue if serious.
- Hyperphosphatemia may increase nephrocalcinosis risk; dose interruption or reduction may be required.
- Hypercalcemia: monitor calcium and PTH in high-risk patients; do not administer in moderate to severe hypercalcemia until managed.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Burosumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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同じ分類のほかの薬剤
よくある質問
What is Burosumab used for?
Burosumab is a medicine in the class miscellaneous. It is used for Hypophosphatemia.
What side effects have been reported with Burosumab?
Pyrexia, Injection site reaction, Cough, Vomiting, Headache, Tooth abscess.
Can Burosumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy. Breastfeeding: Unknown. No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
What does Burosumab interact with?
MediHelp does not list a checked interaction for Burosumab yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
