医薬品リファレンス
Concizumab
Concizumab is a medicine in the class miscellaneous. It is used for hemophilia a.
- 薬効分類: Miscellaneous
- 効能・効果: hemophilia a
最終更新日 出典: US FDA label
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- B02BX10
- 一般的な剤形
- 注射剤
- 既知の相互作用
- 2 (重大: 2)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Monoclonal antibody antagonist of tissue factor pathway inhibitor (TFPI). Inhibiting TFPI enhances FXa production during initiation of coagulation, improving thrombin generation and clot formation regardless of inhibitor status.
成人の通常用量（添付文書の要約）
Routine prophylaxis in hemophilia A or B: Day 1 loading dose 1 mg/kg subcutaneously; Day 2 onward 0.2 mg/kg once daily until the maintenance dose is individualized.
妊娠と授乳
- 妊娠
- Unsafe May cause fetal harm based on mechanism of action; use only if benefit outweighs risk. Highly effective contraception advised during and for 7 weeks after treatment.
- 授乳
- Unknown No information on presence in milk. Risk to infant cannot be excluded in the first days after birth; afterwards it could be used if clinically needed.
報告されている副作用
- Injection site reactions
- Headache
- Urticaria
禁忌
- History of known serious hypersensitivity to Alhemo or its components or inactive ingredients.
注意が必要な方
- Thromboembolic events (venous and arterial) occurred in 1.9% of patients; monitor and discontinue if suspected.
- Hypersensitivity reactions including anaphylaxis can occur; discontinue if severe.
- Increases fibrin D-dimer and prothrombin fragment 1.2; these biomarkers may not be reliable for suspected thrombosis.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (2)
- Concizumab + Factor ix Major
- Concizumab + Factor viii Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Concizumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
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同じ分類のほかの薬剤
よくある質問
What is Concizumab used for?
Concizumab is a medicine in the class miscellaneous. It is used for Hemophilia a, Hemophilia b.
What side effects have been reported with Concizumab?
Injection site reactions, Headache, Urticaria.
Can Concizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on mechanism of action; use only if benefit outweighs risk. Highly effective contraception advised during and for 7 weeks after treatment. Breastfeeding: Unknown. No information on presence in milk. Risk to infant cannot be excluded in the first days after birth; afterwards it could be used if clinically needed.
What does Concizumab interact with?
MediHelp lists 2 known interactions for Concizumab. Major: 2. The most serious include Factor ix, Factor viii.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
