医薬品リファレンス
Delgocitinib
Delgocitinib is a medicine in the class miscellaneous. It is used for eczema.
- 薬効分類: Miscellaneous
- 効能・効果: eczema
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- D11AH11
- 一般的な剤形
- クリーム剤
- 一般的な規格
- 20 mg/g
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Janus kinase (JAK) inhibitor that inhibits the activity of JAK1, JAK2, JAK3 and TYK2, interfering with JAK-STAT cytokine signaling. The exact mechanism in chronic hand eczema is not known.
成人の通常用量（添付文書の要約）
Moderate to severe chronic hand eczema: apply a thin layer topically twice daily to affected areas of the hands and wrists only; do not use more than 30 grams per 2 weeks or 60 grams per month
妊娠と授乳
- 妊娠
- Unknown Cream for chronic hand eczema; little is absorbed through the skin. Human data are insufficient; oral doses over 100 times human exposure caused no developmental harm in rats and rabbits. Use only if needed.
- 授乳
- Unknown No human milk data; present in rat milk after oral dosing. Topical use gives low exposure. US label: weigh breastfeeding against need; avoid direct infant contact with the nipple area right after applying to hands or wrists.
報告されている副作用
- Application site pain
- Paresthesia
- Pruritus
- Erythema
- Bacterial skin infections including finger cellulitis and paronychia
- Leukopenia and neutropenia
禁忌
- None
注意が必要な方
- May increase risk of infections, including eczema herpeticum; avoid use in patients with an active or serious infection.
- Viral reactivation (e.g., herpes zoster) reported; not recommended in active hepatitis B or C; consider hepatitis screening.
- Non-melanoma skin cancers reported; periodic skin examinations recommended; limit sun exposure.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
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アカウントを作成してPro+トライアルを始めると、Delgocitinibの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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よくある質問
What is Delgocitinib used for?
Delgocitinib is a medicine in the class miscellaneous. It is used for Eczema.
What side effects have been reported with Delgocitinib?
Application site pain, Paresthesia, Pruritus, Erythema, Bacterial skin infections including finger cellulitis and paronychia, Leukopenia and neutropenia.
Can Delgocitinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Cream for chronic hand eczema; little is absorbed through the skin. Human data are insufficient; oral doses over 100 times human exposure caused no developmental harm in rats and rabbits. Use only if needed. Breastfeeding: Unknown. No human milk data; present in rat milk after oral dosing. Topical use gives low exposure. US label: weigh breastfeeding against need; avoid direct infant contact with the nipple area right after applying to hands or wrists.
What does Delgocitinib interact with?
MediHelp does not list a checked interaction for Delgocitinib yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
