医薬品リファレンス
Iptacopan
Iptacopan is a medicine in the class miscellaneous. It is used for nephropathy.
- 薬効分類: Miscellaneous
- 効能・効果: nephropathy
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- 一般的な剤形
- カプセル剤
- 一般的な規格
- 200 mg
- 既知の相互作用
- 5 (中等度: 5)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Iptacopan binds Factor B of the alternative complement pathway and regulates C3 cleavage, generation of downstream effectors and amplification of the terminal pathway. In PNH it controls both C3b-mediated extravascular hemolysis and terminal complement-mediated intravascular hemolysis.
成人の通常用量（添付文書の要約）
PNH, IgAN, C3G: 200 mg orally twice daily, without regard to food; swallow capsules whole
妊娠と授乳
- 妊娠
- Unknown Human data are insufficient to show a risk; no fetal harm in rats or rabbits at 4 to 6 times human exposure. Untreated PNH or the kidney diseases it treats carry serious risks in pregnancy. US label: use may be considered after weighing risks and benefits.
- 授乳
- Unknown No data on milk or infant effects. LactMed repeats the label advice. US label: stop breastfeeding during treatment and for 5 days after the last dose because of possible serious infant reactions (a general precaution; no specific harm is known).
報告されている副作用
- Headache
- Nasopharyngitis
- Diarrhea
- Abdominal pain
- Bacterial infection
- Viral infection
警告（枠囲み警告）
- Complement inhibitor that increases the risk of serious, life-threatening or fatal infections caused by encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b). Complete or update vaccination at least 2 weeks before the first dose unless delaying therapy is riskier, following ACIP recommendations. Risk persists even with vaccine antibodies. Monitor for early signs of infection and evaluate immediately. Available only through the FABHALTA REMS.
禁忌
- Serious hypersensitivity to iptacopan or any of the excipients.
- Initiation in patients with unresolved serious infection caused by encapsulated bacteria.
注意が必要な方
- Serious infections with encapsulated bacteria; if urgent therapy is needed in patients not up to date on vaccines, give antibacterial prophylaxis and vaccinate as soon as possible.
- Available only through the FABHALTA REMS; prescribers and pharmacies must be certified.
- PNH: after discontinuation, monitor for at least 2 weeks for signs and symptoms of hemolysis.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (5)
- Carbamazepine + Iptacopan Moderate
- Gemfibrozil + Iptacopan Moderate
- Iptacopan + Phenytoin Moderate
- Iptacopan + Rifampicin Moderate
- Iptacopan + Secobarbital Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Iptacopanの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
よくある質問
What is Iptacopan used for?
Iptacopan is a medicine in the class miscellaneous. It is used for Nephropathy.
What side effects have been reported with Iptacopan?
Headache, Nasopharyngitis, Diarrhea, Abdominal pain, Bacterial infection, Viral infection. Serious warning: Complement inhibitor that increases the risk of serious, life-threatening or fatal infections caused by encapsulated bacteria (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae type b).
Can Iptacopan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Human data are insufficient to show a risk; no fetal harm in rats or rabbits at 4 to 6 times human exposure. Untreated PNH or the kidney diseases it treats carry serious risks in pregnancy. US label: use may be considered after weighing risks and benefits. Breastfeeding: Unknown. No data on milk or infant effects. LactMed repeats the label advice. US label: stop breastfeeding during treatment and for 5 days after the last dose because of possible serious infant reactions (a general precaution; no specific harm is known).
What does Iptacopan interact with?
MediHelp lists 5 known interactions for Iptacopan. Moderate: 5. The most serious include Carbamazepine, Gemfibrozil, Phenytoin.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
