医薬品リファレンス
Marstacimab
Marstacimab is a medicine in the class cardiovascular. It is used for hemophilia a.
- 薬効分類: Cardiovascular
- 効能・効果: hemophilia a
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Cardiovascular
- ATCコード
- B02BX11
- 一般的な剤形
- 注射剤
- 既知の相互作用
- 1 (重大: 1)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Human monoclonal IgG1 antibody directed against Kunitz domain 2 (K2) of TFPI that neutralizes TFPI activity and enhances coagulation.
成人の通常用量（添付文書の要約）
Routine prophylaxis in hemophilia A or B, adults and patients 12 years and older: loading dose 300 mg (two 150 mg injections) subcutaneous once
妊娠と授乳
- 妊娠
- Unsafe May cause fetal harm based on how it works (it blocks a natural anticoagulant, TFPI); no human data and no animal reproduction studies. Antibodies cross the placenta. Use effective contraception during treatment and for 2 months after the last dose.
- 授乳
- Unknown No data on passage into milk. As a large antibody, milk levels are likely very low and poorly absorbed. LactMed: use with caution, especially with a newborn or preterm infant; waiting 2 weeks after birth may reduce transfer.
報告されている副作用
- Injection site reaction
- Headache
- Pyrexia
- Arthralgia
- Diarrhea
- Pruritus
禁忌
- None.
注意が必要な方
- Thromboembolic events may occur; interrupt prophylaxis if findings consistent with thromboembolism occur. Not studied in patients with prior thromboembolic events.
- Hypersensitivity reactions (including urticaria and pruritus) may occur; discontinue and seek emergency treatment if severe.
- May cause fetal harm; advise effective contraception during treatment and for 2 months after last dose.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (1)
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Marstacimabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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同じ分類のほかの薬剤
よくある質問
What is Marstacimab used for?
Marstacimab is a medicine in the class cardiovascular. It is used for Hemophilia a, Hemophilia b.
What side effects have been reported with Marstacimab?
Injection site reaction, Headache, Pyrexia, Arthralgia, Diarrhea, Pruritus.
Can Marstacimab be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm based on how it works (it blocks a natural anticoagulant, TFPI); no human data and no animal reproduction studies. Antibodies cross the placenta. Use effective contraception during treatment and for 2 months after the last dose. Breastfeeding: Unknown. No data on passage into milk. As a large antibody, milk levels are likely very low and poorly absorbed. LactMed: use with caution, especially with a newborn or preterm infant; waiting 2 weeks after birth may reduce transfer.
What does Marstacimab interact with?
MediHelp lists 1 known interactions for Marstacimab. Major: 1. The most serious include Factor viii.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
