医薬品リファレンス
Ornithine aspartate
Ornithine aspartate is a medicine in the class gastrointestinal tract. It is used for hepatic encephalopathy.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: hepatic encephalopathy
最終更新日
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要点
- 薬効分類
- Gastrointestinal Tract
何に使われるか
作用のしくみ
L-ornithine L-aspartate supplies two amino acids that lower blood ammonia. Ornithine activates the hepatic urea cycle (carbamoyl phosphate synthetase) and is a substrate for it, increasing conversion of ammonia to urea in periportal hepatocytes.
成人の通常用量（添付文書の要約）
Hepatic encephalopathy (latent or manifest), oral granules: 3 to 6 g (1 to 2 sachets of 3 g) up to three times daily. Usual maximum is 18 g/day.
妊娠と授乳
- 妊娠
- Unknown No adequate human data. Labels (e.g. Hepa-Merz) advise avoiding it in pregnancy unless clearly necessary. Ornithine and aspartate are natural amino acids, but high doses used for liver disease have not been studied in pregnancy.
- 授乳
- Unknown Not known if it passes into milk; no LactMed or e-lactancia record. Labels: avoid breastfeeding during treatment unless clearly necessary. Both components are natural amino acids, but high-dose effects on the infant are unstudied; avoid if possible or watch the infant.
報告されている副作用
- Nausea
- Vomiting
- Abdominal pain
- Flatulence
- Diarrhoea
- Limb pain
禁忌
- Hypersensitivity to ornithine aspartate or to any of the excipients.
- Severe renal insufficiency (serum creatinine above 3 mg/100 mL).
注意が必要な方
- With high doses, monitor serum and urine urea levels.
- Do not exceed an IV infusion rate of 5 g per hour; faster infusion increases nausea and vomiting.
- Hepatic encephalopathy may impair the ability to drive and use machines; take this into account during treatment.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
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アカウントを作成してPro+トライアルを始めると、Ornithine aspartateの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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よくある質問
What is Ornithine aspartate used for?
Ornithine aspartate is a medicine in the class gastrointestinal tract. It is used for Hepatic encephalopathy.
What side effects have been reported with Ornithine aspartate?
Nausea, Vomiting, Abdominal pain, Flatulence, Diarrhoea, Limb pain.
Can Ornithine aspartate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Labels (e.g. Hepa-Merz) advise avoiding it in pregnancy unless clearly necessary. Ornithine and aspartate are natural amino acids, but high doses used for liver disease have not been studied in pregnancy. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed or e-lactancia record. Labels: avoid breastfeeding during treatment unless clearly necessary. Both components are natural amino acids, but high-dose effects on the infant are unstudied; avoid if possible or watch the infant.
What does Ornithine aspartate interact with?
MediHelp does not list a checked interaction for Ornithine aspartate yet. Always tell your pharmacist about every medicine you take.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
