医薬品リファレンス
Panobinostat
Panobinostat is a medicine in the class oncology. It is used for multiple myeloma.
- 薬効分類: Oncology
- 効能・効果: multiple myeloma
最終更新日 出典: EMA SmPC
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要点
- 薬効分類
- Oncology
- ATCコード
- L01XH03
- 既知の相互作用
- 107 (併用禁忌: 12 · 重大: 80 · 中等度: 13 · 軽度: 2)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Histone deacetylase (HDAC) inhibitor that inhibits HDAC enzymatic activity at nanomolar concentrations, increasing histone acetylation and causing cell cycle arrest and/or apoptosis of some transformed cells.
成人の通常用量（添付文書の要約）
Relapsed/refractory multiple myeloma (with bortezomib and dexamethasone): 20 mg orally once a day on days 1, 3, 5, 8, 10 and 12 of a 21-day cycle; treat 8 cycles, then 8 more cycles if clinical benefit; up to 16 cycles (48 weeks)
妊娠と授乳
- 妊娠
- Unsafe No clinical studies in pregnancy; animal studies show embryo-foetal toxicity and the potential foetal risk is high. Use only if benefit outweighs risk.
- 授乳
- Unsafe Unknown if excreted in human milk; breast-feeding is contraindicated during treatment.
報告されている副作用
- Diarrhoea
- Fatigue
- Nausea
- Vomiting
- Thrombocytopenia
- Anaemia
禁忌
- Hypersensitivity to the active substance or any excipient.
- Breast-feeding.
注意が必要な方
- Severe thrombocytopenia, neutropenia and anaemia: perform a complete blood count before treatment and monitor frequently.
- Haemorrhage, including fatal GI and pulmonary haemorrhage; higher risk with coagulation disorders or anticoagulants.
- Serious and fatal infections; do not start in active infection.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (107)
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
- Panobinostat + Pimozide Contraindicated
- Panobinostat + Quinidine Contraindicated
- Panobinostat + Sotalol Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Panobinostatの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Panobinostat used for?
Panobinostat is a medicine in the class oncology. It is used for Multiple myeloma.
What side effects have been reported with Panobinostat?
Diarrhoea, Fatigue, Nausea, Vomiting, Thrombocytopenia, Anaemia.
Can Panobinostat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical studies in pregnancy; animal studies show embryo-foetal toxicity and the potential foetal risk is high. Use only if benefit outweighs risk. Breastfeeding: Unsafe. Unknown if excreted in human milk; breast-feeding is contraindicated during treatment.
What does Panobinostat interact with?
MediHelp lists 107 known interactions for Panobinostat. Contraindicated: 12 · Major: 80 · Moderate: 13 · Minor: 2. The most serious include Amiodarone, Anagrelide, Chloroquine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
