医薬品リファレンス
Rozanolixizumab
Rozanolixizumab is a medicine in the class miscellaneous. It is used for myasthenia gravis.
- 薬効分類: Miscellaneous
- 効能・効果: myasthenia gravis
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
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要点
- 薬効分類
- Miscellaneous
- ATCコード
- L04AL02
- 一般的な剤形
- 注射剤
- 一般的な規格
- 140 mg/ml
- 既知の相互作用
- 26 (重大: 1 · 中等度: 25)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Humanized IgG4 monoclonal antibody that binds the neonatal Fc receptor (FcRn), reducing circulating IgG.
成人の通常用量（添付文書の要約）
Generalized myasthenia gravis, body weight less than 50 kg: 420 mg (3 mL), subcutaneous infusion, once weekly for 6 weeks
妊娠と授乳
- 妊娠
- Unknown Limited human data. US label: in monkeys it caused embryo death, low offspring weight and weak immune function at 10 to 30 times the human dose without maternal toxicity; the EU label reads the same studies as low IgG only. It lowers IgG passed to the baby; weigh live vaccines for the infant.
- 授乳
- Unknown No human milk data; IgG passes into milk. US label: weigh benefits. EU label: a risk cannot be excluded in the first days after birth; afterwards consider use only if the benefit outweighs the risk. No LactMed record. A large antibody, so infant absorption is likely low.
報告されている副作用
- Headache
- Infections
- Diarrhea
- Pyrexia
- Hypersensitivity reactions
- Nausea
注意が必要な方
- Infections: may increase infection risk; delay in active infection, monitor, and consider withholding for serious infection.
- Live or live-attenuated vaccines are not recommended during treatment because of reduced IgG.
- Aseptic meningitis: serious cases reported; start diagnostic workup and treatment if symptoms develop.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (26)
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
- Denosumab + Rozanolixizumab Moderate
- Etanercept + Rozanolixizumab Moderate
- Galcanezumab + Rozanolixizumab Moderate
- Golimumab + Rozanolixizumab Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Rozanolixizumabの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Rozanolixizumab used for?
Rozanolixizumab is a medicine in the class miscellaneous. It is used for Myasthenia gravis.
What side effects have been reported with Rozanolixizumab?
Headache, Infections, Diarrhea, Pyrexia, Hypersensitivity reactions, Nausea.
Can Rozanolixizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. US label: in monkeys it caused embryo death, low offspring weight and weak immune function at 10 to 30 times the human dose without maternal toxicity; the EU label reads the same studies as low IgG only. It lowers IgG passed to the baby; weigh live vaccines for the infant. Breastfeeding: Unknown. No human milk data; IgG passes into milk. US label: weigh benefits. EU label: a risk cannot be excluded in the first days after birth; afterwards consider use only if the benefit outweighs the risk. No LactMed record. A large antibody, so infant absorption is likely low.
What does Rozanolixizumab interact with?
MediHelp lists 26 known interactions for Rozanolixizumab. Major: 1 · Moderate: 25. The most serious include Upadacitinib, Abatacept, Adalimumab.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
