医薬品リファレンス
Safinamide
Safinamide is a medicine in the class central nervous system. It is used for parkinson disease.
- 薬効分類: Central Nervous System
- 効能・効果: parkinson disease
最終更新日
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要点
- 薬効分類
- Central Nervous System
- 一般的な剤形
- 錠剤
- 一般的な規格
- 50 mg, 100 mg
- 既知の相互作用
- 156 (併用禁忌: 48 · 重大: 34 · 中等度: 36 · 軽度: 38)
- 商品名
- 8
- 国・市場
- 4
何に使われるか
作用のしくみ
Inhibition of MAO-B activity, by blocking the catabolism of dopamine, is thought to result in an increase in dopamine levels and a subsequent increase in dopaminergic activity in the brain The precise mechanism by which safinamide exerts its effect in PD is unknown
成人の通常用量（添付文書の要約）
Initial: 50 mg PO qDay
妊娠と授乳
- 妊娠
- Unsafe No adequate human data. US label: in animals it caused developmental toxicity, including birth defects, at clinically relevant doses, and at lower doses with levodopa/carbidopa. EU label: not recommended in pregnancy; women who could become pregnant need contraception.
- 授乳
- Unknown No human milk data; it passes into rat milk and caused liver toxicity in nursing rat pups. EU label: should not be used while breastfeeding; US label: weigh benefits. LactMed: alternative agents are preferred.
報告されている副作用
- Nausea
- Insomnia
- Orthostatic hypotension
- Hypertension
- Dyskinesia
- ALT or AST increased to >ULN
注意が必要な方
- May cause hallucinations and psychotic behavior; consider dosage reduction or stopping medication if patient develops hallucinations while on therapy
- May cause problems with impulse control/compulsive behaviors; consider dose reduction or stopping medication if a patient develops compulsive behavior while on therapy
- May cause withdrawal-emergent hyperpyrexia and confusion
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (156)
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Safinamideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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同じ分類のほかの薬剤
よくある質問
What is Safinamide used for?
Safinamide is a medicine in the class central nervous system. It is used for Parkinson disease.
What side effects have been reported with Safinamide?
Nausea, Insomnia, Orthostatic hypotension, Hypertension, Dyskinesia, ALT or AST increased to >ULN.
Can Safinamide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No adequate human data. US label: in animals it caused developmental toxicity, including birth defects, at clinically relevant doses, and at lower doses with levodopa/carbidopa. EU label: not recommended in pregnancy; women who could become pregnant need contraception. Breastfeeding: Unknown. No human milk data; it passes into rat milk and caused liver toxicity in nursing rat pups. EU label: should not be used while breastfeeding; US label: weigh benefits. LactMed: alternative agents are preferred.
What does Safinamide interact with?
MediHelp lists 156 known interactions for Safinamide. Contraindicated: 48 · Major: 34 · Moderate: 36 · Minor: 38. The most serious include Amitriptyline, Amoxapine, Amphetamine polistirex.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
