医薬品リファレンス
Somatrogon
Somatrogon is a medicine in the class endocrine. It is used for growth failure.
- 薬効分類: Endocrine
- 効能・効果: growth failure
最終更新日 出典: US FDA label
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このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Endocrine
- ATCコード
- H01AC08
- 一般的な剤形
- 注射剤
- 一般的な規格
- 24 mg
- 既知の相互作用
- 98 (中等度: 57 · 軽度: 41)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Somatrogon-ghla binds the GH receptor and activates the STAT5b signaling pathway, raising serum IGF-1. GH and IGF-1 stimulate metabolic changes, linear growth and growth velocity in pediatric patients with GHD.
妊娠と授乳
- 妊娠
- Unknown No human data for this long-acting growth hormone; no harm in rats at up to 45 times human exposure. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed.
- 授乳
- Unknown No milk data. UK label: decide whether to stop breastfeeding or the drug; US: weigh benefits. LactMed: poorly absorbed orally and unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
報告されている副作用
- Injection site reactions
- Nasopharyngitis
- Headache
- Pyrexia
- Anemia
- Cough
禁忌
- Acute critical illness after open heart surgery, abdominal surgery or multiple accidental trauma, or acute respiratory failure
- Hypersensitivity to somatrogon-ghla or any excipients
- Closed epiphyses
注意が必要な方
- Severe hypersensitivity reactions including anaphylaxis and angioedema may occur; seek prompt medical attention.
- Increased risk of neoplasms; monitor patients with preexisting tumors and childhood cancer survivors; discontinue if malignancy recurs.
- May decrease insulin sensitivity; monitor glucose periodically; antidiabetic doses may need adjustment.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (98)
- Alogliptin + Somatrogon Moderate
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
- Dapagliflozin-metformin + Somatrogon Moderate
- Deflazacort + Somatrogon Moderate
- Desogestrel-ethinyl estradiol + Somatrogon Moderate
- Dexamethasone + Somatrogon Moderate
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Somatrogonの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
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同じ分類のほかの薬剤
よくある質問
What is Somatrogon used for?
Somatrogon is a medicine in the class endocrine. It is used for Growth failure, Growth hormone deficiency.
What side effects have been reported with Somatrogon?
Injection site reactions, Nasopharyngitis, Headache, Pyrexia, Anemia, Cough.
Can Somatrogon be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data for this long-acting growth hormone; no harm in rats at up to 45 times human exposure. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed. Breastfeeding: Unknown. No milk data. UK label: decide whether to stop breastfeeding or the drug; US: weigh benefits. LactMed: poorly absorbed orally and unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
What does Somatrogon interact with?
MediHelp lists 98 known interactions for Somatrogon. Moderate: 57 · Minor: 41. The most serious include Alogliptin, Alogliptin-metformin, Alogliptin-pioglitazone.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
