本文へスキップ
MediHelp
MediHelp 医薬品リファレンス

医薬品リファレンス

Sufentanil

Sufentanil is a medicine in the class musculoskeletal. It is used for balanced anesthesia.

最終更新日 出典: US FDA label, EMA SmPC

医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。

このページの臨床コンテンツは英語でのみ提供されています。

要点

薬効分類
Musculoskeletal
ATCコード
N01AH03
既知の相互作用
162 (重大: 88 · 中等度: 63 · 軽度: 11)
商品名
1
国・市場
1

何に使われるか

作用のしくみ

Sufentanil is an opioid agonist. In balanced general anesthesia it has been reported to be as much as 10 times as potent as fentanyl.

成人の通常用量（添付文書の要約）

Analgesic adjunct to general anesthesia: doses up to 8 mcg/kg IV by slow injection or infusion; total dosage of 1 mcg/kg/hr or less recommended; individualize

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠
Unknown No human data on birth defects; no malformations in animals, but embryo loss in rabbits near the human dose. It crosses the placenta: use near delivery can depress the newborn's breathing; longer use can cause neonatal opioid withdrawal. Widely used epidurally in labour; have naloxone ready.
授乳
Safe Epidural or IV use in labour or briefly after birth transfers little into milk; LactMed: not a reason to stop. Limit postpartum use to a few days, then non-opioid pain relief. US labels: monitor for infant sedation and breathing problems; call a doctor if very sleepy or limp.

報告されている副作用

  • Apnea
  • Rigidity
  • Bradycardia
  • Pruritus (epidural)

警告（枠囲み警告）

  • Exposes users to addiction, abuse and misuse, which can lead to overdose and death; assess risk and reassess regularly. Life-threatening or fatal respiratory depression may occur, especially at initiation or dose increase. Concomitant benzodiazepines or other CNS depressants may cause profound sedation, respiratory depression, coma and death. CYP3A4 inhibitors may raise sufentanil levels and cause fatal respiratory depression; stopping a CYP3A4 inducer may also raise levels; monitor.

禁忌

  • Hypersensitivity to sufentanil (e.g., anaphylaxis)

注意が必要な方

  • Life-threatening respiratory depression; give only by trained persons with resuscitative equipment; respiratory depression may outlast analgesia
  • Increased risk in COPD, elderly, cachectic or debilitated patients; monitor closely
  • Skeletal muscle rigidity; manage with a neuromuscular blocking agent

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (162)

All 162 interactions, with severity and what to do

Pro+会員向け

ページ全体を見る

アカウントを作成してPro+トライアルを始めると、Sufentanilの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • Dosing in older adults
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
  • IV preparation and dilution
無料アカウントを作成 ログイン

WebでPro+を7日間無料でお試し。カード登録不要。

同じ分類のほかの薬剤

よくある質問

What is Sufentanil used for?

Sufentanil is a medicine in the class musculoskeletal. It is used for Balanced anesthesia, General anesthesia.

What side effects have been reported with Sufentanil?

Apnea, Rigidity, Bradycardia, Pruritus (epidural). Serious warning: Exposes users to addiction, abuse and misuse, which can lead to overdose and death; assess risk and reassess regularly.

Can Sufentanil be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. No human data on birth defects; no malformations in animals, but embryo loss in rabbits near the human dose. It crosses the placenta: use near delivery can depress the newborn's breathing; longer use can cause neonatal opioid withdrawal. Widely used epidurally in labour; have naloxone ready. Breastfeeding: Safe. Epidural or IV use in labour or briefly after birth transfers little into milk; LactMed: not a reason to stop. Limit postpartum use to a few days, then non-opioid pain relief. US labels: monitor for infant sedation and breathing problems; call a doctor if very sleepy or limp.

What does Sufentanil interact with?

MediHelp lists 162 known interactions for Sufentanil. Major: 88 · Moderate: 63 · Minor: 11. The most serious include Alprazolam, Amitriptyline, Amobarbital.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

ダウンロード：App Store 入手：Google Play

A–Zで探す · 医薬品リファレンス

アプリを入手 ログイン